2020-21 CAF Champions League
Qualifying Rounds
Preliminary Round
Teams that received a bye to the First Round due to CAF ranking: Raja Casablanca (MAR), Wydad Casablanca (MAR), Al Ahly (EGY), Zamalek (EGY), Espérance de Tunis (TUN), TP Mazembe (COD), AS Vita Club (COD), Mamelodi Sundowns (ZAF), Horoya (GIN), Primeiro de Agosto (AGO)
| Team 1 | Aggregate | Team 2 | 1st Leg | 2nd Leg |
| Ashanti de Siguiri (GIN) | 1-4 | Stade Malien (MLI) | 1-2 | 0-2 (awarded) |
| Gambia Armed Forces (GMB) | 1-3 | Teungueth (SEN) | 1-1 | 0-2 |
| RC Abidjan (CIV) | 2-2 (a) | ASKO Kara (TGO) | 1-0 | 1-2 |
| AS SONIDEP (NIG) | 4-0 | Mogadishu City (SOM) | 2-0 | 2-0 |
| Al Ahly Benghazi (LBY) | w/o | Mekelle 70 Enderta (ETH) | - | - |
| Gazelle (TCD) | w/o | GR/SIAF (ERI) | - | - |
| Forest Rangers (ZMB) | 0-2 | AS Bouenguidi (GAB) | 0-0 | 0-2 |
| Jwaneng Galaxy (BWA) | 5-1 | US Zilimadjou (COM) | 4-0 | 1-1 |
| Young Buffaloes (SWZ) | 1-1 (a) | Le Messager Ngozi (BDI) | 0-0 | 1-1 |
| PWD Bamenda (CMR) | 0-1 | Kaizer Chiefs (ZAF) | 0-1 | 0-0 |
| AS Otohô (COG) | 1-3 | Al Merrikh (SDN) | 1-1 | 0-2 |
| Rahimo (BFA) | 1-2 | Enyimba (NGA) | 0-1 | 1-1 |
| FC Nouadhibou (MRT) | 1-3 | Asante Kotoko (GHA) | 1-1 | 0-2 (awarded) |
| Vipers (UGA) | 0-2 | Al Hilal (SDN) | 0-1 | 0-1 |
| Buffles du Borgou (BEN) | 2-6 | MC Alger (DZA) | 1-1 | 1-5 |
| Mlandege (ZAN) | 1-8 | CS Sfaxien (TUN) | 0-5 | 1-3 |
| Bantu (LSO) | 0-1 | Nkana (ZMB) | 0-1 | 0-0 |
| Akonangui (GNQ) | 2-3 | Petro de Luanda (AGO) | 0-1 | 2-2 |
| Costa do Sol (MOZ) | 1-4 | FC Platinum (ZWE) | 1-2 | 0-2 |
| Plateau United (NGA) | 0-1 | Simba (TZA) | 0-1 | 0-0 |
| CR Belouizdad (DZA) | 4-0 | Al Nasr (LBY) | 2-0 | 2-0 |
| APR (RWA) | 3-4 | Gor Mahia (KEN) | 2-1 | 1-3 |
